Scientist II, In Vivo, Enzymatic and Metabolic Therapeutic Area
Location Petaluma, California Workstyle Onsite Only ApplyWho We Are
BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health.
Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities.
Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best – people with the right technical expertise and a relentless drive to solve real problems – and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we’ve produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options.
About Worldwide Research and Development
From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases.
We are seeking a motivated Scientist with experience in genetic metabolic diseases to join our team. The Scientist will join the Enzymatic and Metabolic In Vivo team to design and execute key in vivo studies focused on developing therapeutics to transform the lives of people with genetic metabolic disorders. This role reports into the In Vivo Lead. The primary role of the Scientist will be in design and execution of in vivo studies as part of the Enzymatic and Metabolic In Vivo Team. They will work collaboratively across the Research and Early Development Department to identify, develop and execute project strategies for in vivo testing of novel therapeutics. Areas of focus will span from animal model development to testing novel therapeutic approaches for genetic metabolic disorders. Thesuccessfulcandidatewillhaveastrongbackgroundinmetabolic and enzymatic biology,withdemonstrated experience intheuseof modelsystemsinresearch.Experiencewithinvivomodelsofdiseaseandacollaborativemindsetiscritical.While someindustryexperience isaplus,it isnotrequired.
Thesuccessfulcandidatewillcontributein vivomodelevaluationandsupporttoprojectteamsthatsupporttheproject goals.Includinginvivostudydesign,handsoninvivostudyperformance,selectionandcharacterizationofanimal models,as well asapplicationof in vivo methodsand techniques.Strongwrittencommunicationskills are criticalfor FDA filings,writingIACUCprotocols,communicatingscientificstrategy,monitoringinvivostudiesandcollaboratingwith CRO's, tissue collection, and sample management.The successful candidate will also have experiencewith in vivo technical tasks including but not limited todosing techniques (SC, IP, IV, RO, PO), blood collection (tail nick, saphenous vein puncture), and IVIS imaging.
Theidealcandidate willhavePostdoctoralAcademic or Biotech/Pharmaindustryinvivoexperience inthemetabolic diseasefield.Theidealcandidate willhavehands-on experience withanimalmodels of metabolic/enzymaticdisease, a proventrackrecordofhigh-quality science. Proficiency withinvivomethodssuchasadministrationoftestarticles,perfusionandtissuecollection,bloodcollection,aswellasrodentsurgicalmodelsisrequired.Candidatelevelathirewilldependoneducationandexperience.
Responsibilities:
Research Support
- Conductresearchongeneticmetabolic diseases
- Contribute to noveltherapeutic programs basedon innovative, ground-breakingdiscoveries thatcouldleadto new, high-impact opportunities for patients
- Performresearchandpublishfindingsinhigh-impactjournalsandpresentresearchatmajorconferences
- EffectivelypartnerwithotherscientistsandtheResearchandEarlyDevelopmentteamtodevelopandexecute on the program's strategic plan
- Presentprogramdataat arange of internalforums, includingprojectteammeetings,ResearchDepartment Seminars and Research leadership governance forums
- Write,reviewandcontributetostudysynopses,protocols,studyreportsandregulatorydocuments
- Collaborate with various BioMarin functions, CROs, university or analytical laboratories,business partners, as necessarytoensureappropriate/timely progressionof projects
- Participateinmulti-disciplinarydrugdevelopmentteamsandmayleadsub-teams
- Excellentwritten andverbalcommunication
- Abilitytobuild/fosterproductivecross-functionalcollaborationsbothwithinand externaltoBioMarin
- Executehands-onresponsibilities including but notlimitedtoanimalhandlingand restraint(rodents), administration viavariousroutesof administration, includingintravenous(tail-vein),in-lifeanimalhealth monitoringand measurements,clinical observations,sample collection and processing,and accurate data collection.In addition,providingdailycareandmonitoringofmiceorrats,includinghealthchecksand documentation, willalso be required.
- Followallinstitutional,local,andfederalregulationsregardinganimalcareanduse.Adheretosafetyprotocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures andanimal health status including adverse study events. Meticulouselectronic labnotebook documentation.
- Communicate experimental plansandresultsto theprojectteam.Support product development and regulatory filings for pivotal clinical studies.
- Followinstructionsandworkindependentlytoeffectivelymanagetimeandprioritizetasksto ensureall assignmentsarecompletedonorbeforedeadlines.
- Shareyourknowledgeandunderstandingwithotherteammembers
- Document experimental methodsandoutcomes usingElectronic LabNotebooks andgeneration/maintenance of technical procedure documents and SOPs.
- Willingnesstoworkonsitefulltimeincludingoffhoursandweekendsbasedonstudyneeds.
- Otherdutiesasassigned
- Generalrequirementsfortheposition:
- Demonstratedexperienceinmetabolic biology/diseaseresearchinacademiaor industry (preferred) including publication record
- Stronganalytical,problem-solving,anddecision-makingskills
- Strongunderstanding ofgeneticallyengineered models,breeding,andmanagement andGenetherapy modalities
- Excellentoralandwrittencommunication skills
- Passionforcontributingyourscientificskillstodeveloptherapiesforpatientsinneed
- Mustbeabletoutilizecomputerdatabasesforanalysis,dataentry,andpointofcareobservations
- Must beableto work undertimeconstraints withminimal direction ofday-to-day responsibilities,including collaboratively working with multidisciplinary teams
- Mustbeabletoworkwithexternalregulatoryagenciesandaccreditationgroups
- Some"off-corebusinesshours"workrequired
- Completeallcompanytrainingrequirement
- Performall workper designatedsafety standardsand complywith PersonalProtectiveEquipmentrequirements and occupationalhealth toperform work tasks
- Thispositionisanon-sitecriticalrequiredposition
- Otherdutiesasassigned
EducationandExperienceRequirements:
- PhDinarelatedsubjectareawithdemonstrated in vivo researchexperienceinmetabolic disease
- Postdoctoralorpreviousindustryexperience ingenetic metabolic diseases
- Extensivehands-onexperiencewithrodentinvivoworkinthemetabolic field
Thispositionisfull-timeon-siteandbasedinPetaluma,CAwithoccasionalworkonsiteinSanRafael,CA
Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned.
Equal Opportunity Employer/Veterans/Disabled
An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
For additional benefits information, visit: https://careers.biomarin.com/benefits.
- Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.