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SRA I / II- Functional Genomics, Library Screening

Location San Rafael, California
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.

Summary

We are seeking a highly motivated, innovative and team-oriented individual to join the human genetics research group. The successful candidate will utilize the latest technologies to advance our therapeutic research and discovery efforts.  Tasks will include the use of gene editing and NGS technologies to assess genomic functions in vitro. The position requires adaptability, creativity, and a capacity for constant innovation in pursuit of company goals.  

Responsibilities

  • Utilize high throughput molecular biology techniques to construct DNA libraries. Purify DNA libraries, QC using capillary electrophoresis (Fragment analyzer, Bioanalyzer), fluorescence-based assays (Qubit), and sequencing (Sanger, Illumina PacBio).
  • Mammalian tissue culture and DNA/RNA isolation. Analysis of gene expression and function by qPCR, ddPCR, RNA-seq, scRNA-seq. Analysis of gDNA by Nextera XT library preparation and next generation sequencing.
  • Develop phenotypic and functional screening assays in collaboration with cross-functional teams by generating cell lines, creating plasmid or viral libraries, and utilizing RNP based transfections to study genetic variants in the context of disease biology.
  • Utilize data management software such as Excel, Prism, Geneious/SnapGene and computational analysis of genomic data using custom Python scripts.
  • Develop and optimize protocols for next generation sequencing, including the use of liquid handling robots and automation to facilitate library preparation.
  • Work collaboratively in an interdisciplinary team to apply genomic technologies to further target and drug discovery efforts.

Experience

  • Experience with NGS library generation and CRISPR based screening, including the use of liquid handling robotics (Hamilton, Biomek) for mammalian cell culture and downstream library preparation for NGS is preferred.
  • Prior experience with RT-qPCR and other basic molecular biology and biochemical techniques.
  • Experience with Illumina or PacBio library preparation for next generation sequencing.
  • A strong working knowledge of molecular biology techniques such as PCR, electrophoresis, qRT-PCR, ELISA, DNA and protein purification as well as molecular cloning is preferred.

Education

  • Bachelor’s or Master’s degree in Molecular/Cell Biology, Genomics, Bioengineering, or related discipline with 4+ years of research experience in either an academic or industry lab.
  • Strong analytical, written, and verbal communication skills.
  • Track record of productivity and effective projects.
  • Interested in learning new techniques and approaches. Attention to detail, time management and organization skills are critical.

Level Experience & Education:

Senior Research Associate 1:

Bachelor’s degree and at least 6 years of experience; Master’s degree with at least 4 years of relevant experience

Senior Research Associate 2:

Bachelor’s degree and at least 8 years of experience; Master’s degree with at least 6 years of relevant experience


We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

About our location

San Rafael

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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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