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Scientist I, Cell Biology, Biology Research Team

Location San Rafael, California
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.

The Biology Research (BR) group at BioMarin is seeking a highly motivated scientist to conduct preclinical translational research evaluating potential therapeutics for severe rare genetic diseases with unmet medical needs. The successful candidate will partner closely with a team of scientists from BR, other functional groups within BioMarin Research, and bioanalytical sciences to advance our most promising molecules for further development. 

He/she is a highly motivated cell biologist who conceives strategies, leads the development, evaluation and implementation of state-of-the-art cell-based disease models to identify novel therapeutic interventions, in support of preclinical proof-of-concept and mechanisms of actions investigations of novel therapeutics for non-malignant blood disorders. This individual is expected to be a mentor for a recognized area of technical expertise within the department. 

RESPONSIBILITIES:

  • Provide scientific and intellectual input to guide project-related cell biology proof-of-concept and investigative efforts within the context of interdisciplinary project teams.
  • Plan and execute laboratory research.
  • Initiate, direct and execute the development, optimization, qualification of robust cell-based assays
  • Design and conduct cell-based assays (mammalian cell lines, primary cell culture, iPSCs, etc.) for function assessment of therapeutic/genetic interventions
  • Manage external CROs
  • Analyze data with applicable bioinformatics tools/scientifically sound interpretation and present data at group/departmental meetings.
  • Able to troubleshoot experiments based on thorough understanding of assay principles
  • Author technical reports and SOPs associated with the molecular assays developed and qualified.
  • Provide support to collaborating functional groups, as needed
  • Work with junior research associates on experimental design, troubleshooting, assay optimization and data interpretation, if applicable.
  • Maintains broad knowledge of state-of-the-art principles and theories.
  • Participate in exploratory studies driving the evaluation of state-of-the-art new technology platforms, and innovative upgrades for existing assay platforms.
  • Identify, develop and maintain relationships with contract research organizations to maximize group productivity and assure inclusion of latest scientific thinking and guidelines in the research plan.
  • Recruit and manage RAs
  • Contribute to the peer review process, both internally and externally, to help assure BioMarin translational research is conducted at the highest level of quality, integrating business and development objectives.
  • Makes major contributions to scientific literature and conferences.

EDUCATION /REQUIREMENT:

  • A Ph.D. in Cell Biology, Genetics, Immunology or a related field and at least 2 years of postdoctoral or industrial experience are required.
  • Demonstrated experience in tissue culture with iPCS, primary cells (e.g. hepatocytes) and human hematopoietic cells
  • Proficiency with flow cytometry including designing and optimizing multi-parameter flow cytometry panels
  • Experience with confocal microscopy and live-cell imaging. Proficiency in developing and optimizing high-content imaging bioassays independently with limited guidance a plus
  • Proficiency in various molecular biology analytical methods (qPCR or ddPCR), and other standard molecular biology techniques.
  • Background in viral and non-viral gene therapy, cellular or molecular biology is a plus
  • Experience with analytical and/or statistical software (e.g., JMP, Softmax Pro, XLfit, Gen5 etc.), is highly beneficial
  • Demonstrated ability to work in a fast-paced, team-orientated environment with aggressive timelines
  • Passion for continued learning and helping others learn.
  • Maintain detailed records of experimental protocols and data in electronic laboratory notebook in accordance with company policy.
  • Collaborative, team-oriented, consistently looks for win-win solutions to problems.  Ability to interact successfully with team members from a wide variety of functional areas and all levels of contribution and expertise.
  • Publication record supporting a consistent contribution to the success of research projects.
  • Strong communication (verbal and written) skills

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.

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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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