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Scientist 1, Neuroscience / Translational Biology - Research

Location San Rafael, California
BioMarin is a world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases, many of whom are children. These conditions often have few, if any, treatment options. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients. BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Come join our team and make a meaningful impact on patients’ lives.

Role of the Scientist

We are seeking a motivated, capable, creative and team-oriented scientist to support discovery and development of therapeutics to treat genetic neurological disorders. The role will entail designing in vivo studies, evaluating drug pharmacokinetic and pharmacodynamic properties, as well as engineering animal models to address key questions of efficacy, mechanism of action, biomarker identification and translatability. The scientist will be expected to assist with management of animal studies at contract research organizations as well as be tasked with developing new technology/platforms internally. Thought contributions to early stage pipeline are welcome.

Primary Responsibilities

The candidate will join a hard working cross-functional team of translational biologists and technicians to serve as functional lead in designing and implementing in vivo studies for early stage pre-clinical research. The successful candidate will be adept in interacting with multiple diverse teams, CROs and collaborators to guide the development of in vivo assays to test novel therapeutics. Organization, writing skills and ability to analyze and communicate data is essential as the candidate will be expected to generate and manage protocols, instruct others and compose reports in a concise and highly organized fashion. The technical skillsets of the candidate should complement the experience of existing teammates. This includes engineering of genetic models, animal care and husbandry, colony management, fine in-life surgical skills, tissue sampling, dosing multiple routes, electrophysiology both in vitro and in vivo and primary culture capabilities. 

Required Experience:

  • Ph.D. in neuroscience or a closely related field with 0-2 years of postdoc experience
  • Strong publication record in cell and molecular biology and neurophysiology
  • Strong cell culture experience; successful at using iPSC cell systems or tissue cultures
  • Has worked with automatic patch clamp systems, multi electrode array (MEA), small animal EEG or used other tools to probe neuronal activity
  • Experience with stereotaxic injections and fine small animal survival surgery
  • Adept at designing animal behavior experiments.
  • Prior work with oligonucleotides in the CNS a plus.

Additional:

  • Research experience in an industry or quick ability to adapt to industry setting preferred
  • Expected to maintain a flexible schedule, i.e. weekend or holiday work with days off to compensate
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.

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San Rafael

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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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