Scientist 1, Neuroscience / Translational Biology - ResearchLocation San Rafael, California Apply
Role of the Scientist
We are seeking a motivated, capable, creative and team-oriented scientist to support discovery and development of therapeutics to treat genetic neurological disorders. The role will entail designing in vivo studies, evaluating drug pharmacokinetic and pharmacodynamic properties, as well as engineering animal models to address key questions of efficacy, mechanism of action, biomarker identification and translatability. The scientist will be expected to assist with management of animal studies at contract research organizations as well as be tasked with developing new technology/platforms internally. Thought contributions to early stage pipeline are welcome.
The candidate will join a hard working cross-functional team of translational biologists and technicians to serve as functional lead in designing and implementing in vivo studies for early stage pre-clinical research. The successful candidate will be adept in interacting with multiple diverse teams, CROs and collaborators to guide the development of in vivo assays to test novel therapeutics. Organization, writing skills and ability to analyze and communicate data is essential as the candidate will be expected to generate and manage protocols, instruct others and compose reports in a concise and highly organized fashion. The technical skillsets of the candidate should complement the experience of existing teammates. This includes engineering of genetic models, animal care and husbandry, colony management, fine in-life surgical skills, tissue sampling, dosing multiple routes, electrophysiology both in vitro and in vivo and primary culture capabilities.
- Ph.D. in neuroscience or a closely related field with 0-2 years of postdoc experience
- Strong publication record in cell and molecular biology and neurophysiology
- Strong cell culture experience; successful at using iPSC cell systems or tissue cultures
- Has worked with automatic patch clamp systems, multi electrode array (MEA), small animal EEG or used other tools to probe neuronal activity
- Experience with stereotaxic injections and fine small animal survival surgery
- Adept at designing animal behavior experiments.
- Prior work with oligonucleotides in the CNS a plus.
- Research experience in an industry or quick ability to adapt to industry setting preferred
- Expected to maintain a flexible schedule, i.e. weekend or holiday work with days off to compensate