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Scientist 1, Purification Process Development

Location Novato, California
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. Come join our team and make a meaningful impact on patients’ lives.


The Scientist 1 is responsible for the development and characterization of purification processes for therapeutic proteins and gene therapy vectors, and for their implementation in manufacturing facilities.


The Scientist 1 has expertise relevant to the development of purification processes for therapeutic proteins and gene therapy vectors. Working as part of a team, the Scientist strives to design individual process steps and to assemble them into complete processes that meet regulatory requirements and expectations for efficiency and product quality.

On a hands-on basis, the Scientist

-designs and carries out experiments;

-develops and makes use of analytical methods, chiefly HPLC, ddPCR, SDS-PAGE, Western blots, ELISA, and enzyme activity assays;

-runs larger-scale purification trains to provide experimental supplies to other groups;

-takes part in process troubleshooting, and transfer of processes to large-scale manufacturing facilities; and

-communicates with others via presentations and written reports on process descriptions, technical progress, milestones, and challenges.

The Scientist initially will work as an individual contributor, but with time may lead a development group of one or more research associates.  


Required Skills:

The applicant’s chief job responsibilities have to do with protein and viral vector purification projects. Thus, the candidate should have practical experience in the development of methods for purifying proteins or vectors using unit operations such as chromatography, filtration, or ultrafiltration.

The essential function of the job is experimental investigation. The applicant should have advanced skills in experimental design, data analysis, and data presentation.  The Scientist should be capable of generating quality scientific data with limited assistance from coworkers. Evidence of independent scientific thought, as evidenced by original peer-reviewed scientific publications, is required.

Desired Skills:

Experiencerelevant to industry purification process development

Expertise in protein chemistry and/or viral vector structure and function


A Ph.D. degree in chemistry, biochemistry, chemical engineering, or the biological sciences is required. The applicant’s academic training should include exposure to protein chemistry and biophysical chemistry.


Laboratory equipment, such as analytical instruments and chromatography workstations; pilot processing equipment, such as pumps, filtration devices, and chromatography skids.


Other scientists and senior scientists within Process Sciences, Analytical Chemistry, Quality Control, and Formulation; project managers, and laboratory associates.



We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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