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Technical Scientist I, In Vitro Electrophysiology, Biology Research

Location San Rafael, California
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives. 

The mission of Biology Research group is to conduct preclinical translational research evaluating potential therapeutics for severe rare diseases with unmet medical needs. We provide proof-of-concept preclinical data in relevant disease models and understanding of mechanisms of action for these potential therapeutics.

Summary:

A position is available in Biology Research group for a Technical Scientist  who will partner closely with a team of scientists to provide technical assistance and support for research projects. The primary research goals are to investigate the functional and pharmacological properties of ion channel mutations associated with cardiac disorder or CNS disease in heterologous cells and human iPSc cells. He/She will primarily be involved in the development and optimization of in vitro electrophysiology recording for supporting of proof-of concept studies.

Responsibilities:

  • Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches.
  • Record and notebook-keeping.
  • Present data and participate in discussion in group meetings, department meetings, and Early Development team meetings as necessary.
  • Participate in external scientific meetings and contribute to original peer-reviewed publications.
  • Prepare SOPs and other reports and documents to support nonclinical and clinical programs and associated regulatory submissions. This includes qualification protocols, qualification reports, memoranda, and data reports for testing results.
  • Share responsibility for lab management duties.

 Techniques may include:

  •  Experience in in vitro electrophysiology recording (manual patch clamp or automated planar patch clamp) is highly preferred.
  • Experience with data processing and analysis of ion channels.
  • Experience in working with viral vectors (AAV and LV).
  • Experience in basic molecular biology and biochemistry assays.
  • Cell culture (Human iPSC-derived and immortalized cell lines)
  • Perform quantitative analysis within and across multiple experiments, including basic statistical and graphical analysis.
  • Work both independently and collaboratively to advance projects, perform studies with minimal supervision.

Education & Experience:

  • Technical Scientist 1:  Bachelor’s degree and at least 10 years of experience; Master’s degree with at least 8 years of relevant experience


Relocation support is provided

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.

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San Rafael

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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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