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Scientist I (TEMPORARY)

Location San Rafael, California
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives. 

Duties


The Analytical Biochemistry and Cell Biology group within the Research department of BioMarin Pharmaceutical is seeking an exceptional cellular immunologist at the Scientist level to join a matrix team-based research department. The successful candidate will contribute to the development of immunology-related therapeutics and add immunology expertise to project teams.  Applicants should have a PhD in the field of immunology with expertise in autoimmune disease and model systems.  Direct hands on experience in cell culture, molecular biology techniques, and autoimmune animal models is required.  Ability to work collaboratively on project teams, being resourceful, taking initiative, and attention to detail are essential.  Candidates should be scientifically flexible in working in a wide range of disease areas.


Skills


RESPONSIBILITIES


-Immunology assays, applications, and diseases.


-Ex vivo and cell culture based assays – migration/activation, magnetic bead separations, FACS.


-Molecular biology – qPCR, ELISA, multiplex assay, Westerns.



EXPERIENCE



Required Skills:


-PhD degree with extensive experience in cell culture and molecular biology techniques.


-Focused education on autoimmunity and autoantibodies.


-Experience with animal models of autoimmunity.


-Cell culture work with immune cells relevant to autoimmune disease.


-Molecular biology – RNA isolation, ELISA, Western, immunofluorescence.


-Strong organizational and computer skills.



Desired Skills:


-Having glycobiology experience a plus.


-Derivation of clonal cell lines.


-Ex vivo culture and stimulation of human PBMC and/or human cells derived from secondary lymphoid tissue.



EQUIPMENT


Laboratory equipment.



CONTACTS


Must be able to work in a cross-discipline team-based format and present data at internal group and departmental meetings.



Education


Scientist 1:  PhD with 0-2+ years of relevant industry experience.


Skills and Experience


The Skills and Experience match parameters for the candidate are parsed from the Duties, Skills, and Education.


We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

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