Scientist 2, Molecular Genetics and Cellular Biology in Musculoskeletal Therapeutic Area at BioMarin
Skip Navigation

Scientist 2, Molecular Genetics and Cellular Biology in Musculoskeletal Therapeutic Area

Location San Rafael, California Workstyle Onsite Only
Who We Are

For more than two decades, going our own way has led to countless breakthroughs, bettering the lives of those suffering from rare genetic disease. In 1997 we were founded to make a big difference in small patient populations. Now we seek to make an even greater impact by applying the same science-driven, patient-forward approach that propelled our last 25 years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Through our unparalleled expertise in genetics and molecular biology, we will continue to develop targeted therapies that address the root cause of the conditions we seek to treat. Applying our knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The end goal has always been better lives and now we can reach more.


And the more people we reach, the more our impact can grow. We transform lives through genetic discovery.

Our Culture

Our desire to make a positive impact on our patients extends to our employees and BioMarin is committed to fostering an inclusive environment where every person feels seen, valued, and heard – so employees can thrive in all areas of their lives, in and outside of work. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with the ability to develop their long-term careers. Ultimately, we want to be an organization where people enjoy coming to work and take pride in our efforts to help patients.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients’ lives.

POSITION SUMMARY

BioMarin’s Musculoskeletal Therapeutic Area is seeking a highly motivated Scientist I or II to join the team.  We are professional scientists with a passion for making therapeutics that have a big impact on lives and are devoted to sharing scientific findings with the community.  We value kindness and generosity in the workplace, a healthy work/life balance and emphasize mentorship and the growth and support of our colleagues.

The successful candidate will be responsible for the intellectual and hands on evaluation of therapeutic strategies in support of the research pipeline.  In the act of doing so, they will have multidisciplinary interactions with dozens of colleagues throughout Research and across the business.  This is primarily a laboratory-based role where in vitro molecular, cellular, genetic and biochemical methods will be applied.

The successful candidate has:

  • A passion for finding treatments for rare genetic diseases.
  • A strong foundation in molecular, cellular, genetic, and biochemical concepts and methodology as demonstrated through publications and presentations.
  • Demonstrable success in:
    • Designing and carrying out lean sets of experiments that produce actionable data; proposing hypotheses, testing them, and delivering reliable results consistently.
    • Rapidly mastering new fields and methods and connecting with KOLs.
    • Presenting experimental results, conclusions, implications, and next steps.
    • Meticulously adhering to electronic data recording standards.
    • Collaborating and working in teams.
    • Incorporating guidance into project strategies.
    • Knowing the limits of their bandwidth or knowledge and seeking the right help.
    • Taking initiative and being resourceful.
    • Composing clear and impactful written and verbal communications.
    • Working with urgency and efficiency.
    • Leadership and mentorship.
    • Receiving and giving feedback with grace.
    • Automating workflows.
    • Being a tidy and considerate lab citizen.


EXPERIENCE

  • Required Skills:  An expert level ability to develop & conduct the following methods, and to analyze, present, and quickly iterate upon the data generated:
    • Protein quantification: ELISA, Western/WES or other, and a conceptual understanding of LCMS.
    • mRNA/DNA quantification: qPCR, ddPCR, knowledgeable of NGS approaches, prep and analysis.
    • Microscopy: Confocal or other with a breadth of knowledge in sample preparation and image analysis to visualize and quantify cellular events.
    • Deep experience in cell culture approaches: Knowledgeable on cell lines to use for various applications and Flow cytometry or FACS; has applied transfection and transduction approaches, gene editing, and generated edited or transgenic cell lines.
    • Modern and traditional molecular cloning approaches (Gibson, etc).
  • Extra consideration will go to candidates with the following skills/experience:
    • Expertise or knowledge in skeletal or muscle biology and/or disease such as muscular dystrophy and achondroplasia.
    • Expertise in mRNA regulation: transcription, stability, miRNAs, splicing, etc.
    • Liquid handling automation and application of other HTS instrumentation.
    • Experience with therapeutic modality evaluation and/or development: oligonucleotides, small molecules, gene therapy, and/or antibodies.
    • Differentiation of iPSCs into neurons, cardiomyocytes, or myotubes and methods to evaluate the physiology of those cells.
    • Functional Genomics: pooled CRISPR screens, etc.
    • Programming (Python, other).


LEVELING GUIDELINES:

  • Scientist 2: Ph.D. or equivalent relevant experience plus 2-5+ years industry experience.


SUPERVISOR RESPONSIBILITY

No direct reports are associated with this position.



PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.

In the U.S., the salary range for this position is $ 112,000 to $ 168,000 per year, which factors in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. A discretionary bonus and/or long-term incentive units may be provided as part of the compensation package, in addition to the full range of medical, financial, and/or other benefits, dependent on the level and position offered.

About our location

San Rafael

View

Our Benefits

View

Hiring Insights

View
Woman working at a computer
Return to the top of the page