Scientist 1, Protein Sciences & PurificationLocation San Rafael, California Apply
BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.
Scientist 1, Protein Sciences, plays an important role in the discovery-stage research of biotherapeutics gene therapies and small-molecule drug candidates. The Scientist 1 works within multidisciplinary teams of scientists/research associates to provide experimental and/or analytical expertise in designing, purifying and characterizing protein-based drug candidates or drug targets. He or she also uses analytical techniques to do an especially thorough job of characterizing proteins.
As a scientist in the Protein Sciences group within the Genetics Research & Delivery department, the Scientist 1 is responsible for providing expertise in biochemistry, protein chemistry or biophysics (chromatography, HPLC, enzyme activity assays, spectroscopy, Octet, ITC, MALS, and mass spec.) to:
- Design novel biotherapeutics
- Characterize drug target molecules
- Develop protein purification, characterization and analytical methods
- Assist development-stage programs (process development, formulation, etc.)
- Evaluate new project ideas
- Assist in quality and purity assessments of intermediates during purification development
- Develop EIAs and microplate assays
- Study the binding interactions of proteins such as by measuring dissociation constants
- Work with CROs that provide analytical services to the group
The Scientist 1 plans and executes experimental protocols, presents results at project team or departmental meetings, and engages in collaborative teamwork.
Ph.D. degree with 0-2+ years of post-doctoral or industry experience in the fields of analytical chemistry, biophysics, protein biochemistry. Applicants holding an M.S. degree must have 5+ years of relevant industry experience; those holding a B.S. degree 8+ years.
A candidate with a background in biochemistry and protein chemistry is preferred. The ideal candidate not only demonstrates extensive experience in protein purification, but also possesses complementary technical skills in cellular biochemistry, protein chemistry and biophysical bench work. Experience in Akta-based protein purification, ultrafiltration/diafiltration, and clarification processes is required. Experience in bacterial fermentation, cell culture and cell-based assay development is highly desired. The candidate must demonstrate an ability to work collaboratively in teams of scientists/research associates with diverse backgrounds, and efficiently manage time in order to organize, prioritize and execute tasks in a fast-paced work environment. Excellent oral and written communication skills and a high degree of personal responsibility are valued.
The Scientist I reports to the Director, Protein Sciences, and works closely with research associates/other scientists within the Protein Sciences group. In multi-disciplinary project team settings, he or she interacts with project leaders and other project team members. He or she may also interact with external scientists from academic institutions and contract research organizations.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.