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Research Associate II (TEMPORARY)

Location San Rafael, California
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.

Duties


BioAnalytical Sciences develops analytical methods for detection of drug, antibodies to protein therapeutics, and biomarkers in biological matrices from non-clinical and clinical subjects to support projects through multiple stages of development. The qualified candidate plans and performs activities required for Critical Reagent preparation, characterization, and release testing in a regulated environment while exercising significant technical discretion. Responsibilities can include sample preparation, sample analysis, GLP documentation, report and SOP generation, assay validation and troubleshooting.  Level of hire (RA I/II/SRA) dependent on experience. 

  • Produce consistently prepared and well characterized reagents to reduce the risk of assay failure and ensure methods meet regulatory requirements.
  • Responsible for the development and quality of Critical Reagents including purifying proteins, conducting protein conjugations (e.g. biotinylation, ruthenylation using standard chemistry), purifying DNA plasmids, assessing their purity, affinity, and concentration, and generating Certificates of Analysis.
  • Monitors and or trend lot-to-lot variability, and may assist with reagent troubleshooting
  • Enhance the analytical capabilities of the group.
  • Prepare SOPs, reports and documents such as characterization protocols, development reports, and testing data reports.
  • Share responsibility for lab maintenance duties.
  • Participates in meetings and presents data.
  • Responsible for the generation, characterization, and release of critical reagents used in clinical and non-clinical sample analysis, the CRG Research Associate will be a critical service to the assay development and testing groups by building and continuously supplying customized protein reagents for internal and outsourced assays.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.  Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is occasionally exposed to work near moving mechanical parts; fumes or airborne particles; toxic or caustic chemicals; risk of electrical shock and vibration.  The noise level in the work environment is usually moderate.

The employee may frequently be required to sit and talk or hear.  The employee is occasionally required to stand; walk; use hands to finger, handle, or feel; reach with hands and arms; climb or balance; stoop, kneel, crouch, or crawl and taste or smell.  The employee must occasionally lift and/or move up to 25 pounds.  Specific vision abilities by this job include close vision, depth perception and ability to adjust focus.

Skills


Research Associate II: 

  • Required:  Bachelor’s degree and at least 4 years of experience in a bioanalytical laboratory, research laboratory, or biotechnology company.  Master’s degree with at least 2 years of relevant experience.
  • Preferred: Skills with protein conjugations, protein characterization (including SDS-PAGE, Western Blot, HPLC), chromatography systems (experience with Akta instruments preferred), DNA plasmid purification and characterization, and other analytical methods or analytical experience in a regulated lab environment
  • Preferred: Experience with generating Standard Operating Procedures and Protocols.
  • Preferred: Excellent writing and verbal communications skills.
  • Preferred: Analyzes data and summarizes results independently, then proposes interpretations and next steps in consultation with supervisor

Senior Research Associate I: 

  • Required:  Bachelor’s degree and at least 6 years of relevant experience; Master’s degree with at least 4 years of relevant experience
  • Preferred: Skills with protein conjugations, protein characterization (including SDS-PAGE, Western Blot, HPLC), chromatography systems (experience with Akta instruments preferred), DNA plasmid purification and characterization, and other analytical methods or analytical experience in a regulated lab environment
  • Preferred:  Independently designs, executes, troubleshoots, and interprets complex sets of experiments or procedures.
  • Preferred:  Ability to manage projects of significant complexity across various groups/functions. 
  • Preferred:  Give effective oral presentations at departments and interdepartmental meetings.

Education


  • Bachelor’s degree and at least 4 years of experience in a bioanalytical laboratory, research laboratory, or biotechnology company.  Master’s degree with at least 2 years of relevant experience.


PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.

About our location

San Rafael

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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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