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Research Associate 2 – AAV Gene Therapy / Cardiac Cell Biology

Location:San Rafael, California

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Overview

With accelerated review underway in the United States and Europe for our Hemophilia A drug, a second gene therapy program entering the clinic for PKU patients, and a third program in late research for Hereditary Angioedema, BioMarin continues to pioneer innovative approaches to treating rare diseases. Our commitment to gene therapy is further underscored by having developed the first and largest gene therapy manufacturing facility in the world. The scientific possibilities and the hope we offer to patients with rare diseases is enormous.

BioMarin is a midsize biotechnology company with a market cap of approximately 18 billion. Over the course of our 22 year history we have successfully launched 7 drugs for the treatment of rare diseases. Our success is due to our scientific rigor and our ability to leverage multiple therapeutic modalities. BioMarin is based in the San Francisco Bay Area and offers a comprehensive relocation program.

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Success Profile

Check out the traits we’re looking for and see if you have the right mix.

  • Decision Making
  • Influence
  • Collaboration
  • Agility
  • Leadership
  • Intellectual Curiosity

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Our CULTURE

  • Patient Focused
  • Results Oriented
  • Pioneering Science
  • Cross Functional Collaboration
  • Willing to try new ways to look at problems

Benefits

  • Healthcare

  • Medical

  • Dental

  • Vision

  • Health & Wellness Programs

  • 401(k)/Retirement plans

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" BioMarin has this, in their own DNA, an approach: they only work on projects for which they know the underlying biology."
Lon C., Chief Scientific Officer
"We’ve got to understand: What are the problems other people are trying to solve? And do we have a better way of fundamentally doing that?"
Brinda B, GVP, Corporate and Business Development

Responsibilities

BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.

We are seeking a highly motivated and skilled individual to join our innovative and collaborative Cell Biology Group within Biology Research. The successful candidate will perform in vitro cell-based assays and provide biochemical assay support to early stage cardiac gene therapy programs within Research. Cell-based assays developed by the successful candidate will aid in identification and characterization of novel therapeutics for cardiac indications with high unmet need.

Position Requirements/Responsibilities

  • Execute, optimize, and troubleshoot cell-based assays with minimal supervision.
  • Experience with AAV-mediated gene expression in mammalian cells.
  • Ability to prioritize tasks efficiently to deliver reliable results according to projected timelines, with minimal supervision.
  • Thorough documentation of experimental methods, procedures, and results.
  • Analyze, summarize, and interpret data to communicate experimental findings.
  • Participate in scientific discussions within group as well as presentation of results in group meetings.
  • Willingness to learn and accept new responsibilities.
  • Must be able to work in a team environment, with a proven track record of collaboration.

Skills

  • Proficient with culturing adherent mammalian cells, particularly iPS cardiomyocytes and/or immortalized cardiomyocytes.
  • Protein analysis: SDS-PAGE, Western blotting, activity assays, ELISA.
  • Fluorescent microscopy/immunostaining, familiarity with high content imaging is a plus.
  • Proficiency with basic data analysis programs (Excel, GraphPad Prism, etc).
  • High attention to detail and strong organizational/interpersonal skills.

Experience & Education

  • Research Associate 2: Bachelor’s Degree with at least 4 years of experience or master’s degree with at least 2 years of experience

Supervisor Responsibility

No direct reports associated with this position



PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.
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About our location

San Rafael

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Meet Our Team

From internationally renowned scientists to patient advocates, BioMarin Hemophilia has brought together the right people.

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In the News

BioMarin has entered into a preclinical collaboration and license agreement with DiNAQOR, a gene therapy platform company, to develop novel gene therapies to treat rare genetic cardiomyopathies.

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