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Intern - Investigative Molecular Neuroscience

Location San Rafael, California
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives. 

SUMMARY:

The BioMarin Summer Internship Program will enable students to gain valuable experience and knowledge of the processes and systems within BioMarin, while gaining an insight into the pharmaceutical/biotech industry.

JOB DESCRIPTION:

The successful candidate will join the Department of Translational Biology whose role is to conduct preclinical translational research evaluating potential therapeutics for severe rare diseases with unmet medical needs. We provide proof-of-concept preclinical data that aims to decipher the pathophysiologic mechanisms underlying the disease of relevant animal models, and to test the efficacy of potential therapeutics by means of correcting the disease phenotype.

Intern Project on Investigative Molecular Pathology:

The research summer intern will work on one major and one minor neuroscience projects over the 3-month internship. The successful candidate will partner closely with a team of scientists from the Research department at Biomarin and will report to a veterinary pathologist. He/She/They will primarily be involved in the development of novel in vitro systems (cell culture/ organotypic slices) that can reproduce disease features as well as the implementation of disease associated tissue biomarkers by means of histological-based platforms such as immunohistochemistry and in situ hybridization.

The responsibilities of the candidate will be:

  • Brain/ Spinal cord/ Muscle co-cultures
  • Characterization of human neural cell cultures
  • Setting-up an IHC toolkit in tissue samples
  • Digital imaging transfer of laboratory results using conventional and fluorescence microscopy and glass slide scanning.
  • Acquisition of images, and quantitative and graphical data using appropriate image processing and statistical software.
  • Notebook keeping, compilation of data and interpretation into power point presentations.
  • Provide verbal and written communication of results, conclusions, and implications to multidisciplinary teams.


Qualifications/Requirements:

  • Applicants should be at least in their 3rd or 4th year obtaining either a BA/BS in Biology or Biochemistry. Applicants who are enrolled in a MS, PhD in Neuroscience and/or Anatomic Pathology Residency Programs are highly encouraged to apply. Ideal candidates would have previous laboratory experience in in vitro cell/tissue systems, histology and immunohistochemistry, and use of fluorescence microscopy and digital image analysis. The position requires self-motivation, teamwork, and dedication to quality in a fast-paced scientific setting. 
  • Student must be returning to school in the Fall Term OR has graduated within the 1 year of the start of the intern program
  • Must be available to work 40 hours a week
  • Housing and Transportation is responsibility of the Intern

Benefits of a BioMarin Internship:

  • Apply skills and knowledge learned in the classroom to on-the-job experiences
  • Comprehensive, value-added project(s)
  • Work in teams and with colleagues in a professional environment
  • Develop technical skills specific to your major
  • Provides opportunities for professional development by building relationships and learning about other parts of the business
  • Weekly lunch seminar series with Executive Staff
  • End of summer poster presentation to the BioMarin Community
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

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San Rafael

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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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