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Executive / Senior Director, Core Team Leader, Gene Therapy for Hemophilia A

Location:San Rafael, California



With accelerated review underway in the United States and Europe for our Hemophilia A drug, a second gene therapy program entering the clinic for PKU patients, and a third program in late research for Hereditary Angioedema, BioMarin continues to pioneer innovative approaches to treating rare diseases. Our commitment to gene therapy is further underscored by having developed the first and largest gene therapy manufacturing facility in the world. The scientific possibilities and the hope we offer to patients with rare diseases is enormous.

BioMarin is a midsize biotechnology company with a market cap of approximately 18 billion. Over the course of our 22 year history we have successfully launched 7 drugs for the treatment of rare diseases. Our success is due to our scientific rigor and our ability to leverage multiple therapeutic modalities. BioMarin is based in the San Francisco Bay Area and offers a comprehensive relocation program.

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Success Profile

Check out the traits we’re looking for and see if you have the right mix.

  • Decision Making
  • Influence
  • Collaboration
  • Agility
  • Leadership
  • Intellectual Curiosity

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  • Patient Focused
  • Results Oriented
  • Pioneering Science
  • Cross Functional Collaboration
  • Willing to try new ways to look at problems


  • Healthcare

  • Medical

  • Dental

  • Vision

  • Health & Wellness Programs

  • 401(k)/Retirement plans

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" BioMarin has this, in their own DNA, an approach: they only work on projects for which they know the underlying biology."
Lon C., Chief Scientific Officer
"We’ve got to understand: What are the problems other people are trying to solve? And do we have a better way of fundamentally doing that?"
Brinda B, GVP, Corporate and Business Development


BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

By providing a foundation for all operations company wide, BioMarin’s General and Administrative teams support our mission of providing first and best in class therapeutics to patients who live with rare diseases. Our teams include groups such as finance, legal, human resources, corporate compliance and ethics, and information technology. Come join our team and make a meaningful impact on patients’ lives.

BioMarin’s Product Portfolio Development (PPD) is responsible for BioMarin’s corporate and R&D governance, business operating model (core teams and sub-teams)Competitive Intelligence, Global Patient Advocacy and Engagement  and portfolio strategy. PPD integrates overall product strategy and ensures planning and timely execution to inform decision making and development of therapies and life cycle strategies at BioMarin.

Program & Position Impact:

At BioMarin we work for hope.  Our Gene Therapy for Hemophilia A Program embodies this statement.  BioMarin is developing gene therapy via an AAV-factor VIII vector, valoctocogene roxaparvovec, an investigational drug for the treatment of Hemophilia A.

This is an opportunity to champion this transformative gene therapy through approval, launch and lead lifecycle efforts.  BMRN has a strong pipeline of gene therapy assets focused on populations with significant unmet need and you will have the opportunity to potentially lead a global launch of this transformative medicine.

About the Team:

The Core Team Leader Group is part of BioMarin’s Corporate Product Portfolio Development function which reports to the Chief Scientific Strategy Officer.  Product Portfolio Development is responsible for BioMarin’s corporate and product governance, business operating model (core teams and partner teams), portfolio strategy and business financial planning, strategic business insights and Competitive Intelligence.

Core Team Leader (CTL) Position:

CTL is the product champion and leads a team of functional leaders that together develop product strategy which is reviewed and approved by BioMarin governance.  CTL is the primary liaison with executive management and has overall accountability to executive management for the integrated product strategy. In collaboration with core team (CT) members, the CTL ensures progress and execution against plans and as the leader of the CT is the primary contact for internal stakeholders. As a senior leader in the core team leader group, is a role model, mentors peers and contributes to key core team processes and initiatives.


  • 12+ years experience in the biotechnology/ pharmaceutical industry. Rare disease experience is a plus.
  • 5+ years of experience leading a core/cross functional strategy team for an investigational or marketed therapy or as commercial leader who has both development and launch experience.
  • The successful candidate will also demonstrate strong matrix leadership ability and professional credibility to influence a highly intelligent and sophisticated audience of colleagues, partners, and external constituents.

This individual must be a self-starter and possess excellent leadership, influencing and communication skills, as they will be applied at all levels, including at the core team, interactions with the executive team, and presentations to internal and external audiences.

 General CTL Responsibilities:

  1. Program Strategy
  • Lead the CT in the evolving Target Product Profile for launch  to maximize Valrox’s potential for Hem A patients and for the business
  • Ensure integrated stage-based product plans that are aligned with program strategy and ensures assumptions and drivers are aligned with plans to inform financial planning
  • Establish strong partnerships with all functional stakeholders, specifically Clinical Science, Medical Affairs, Regulatory and Commercial to ensure approval and launch success.
  • Ensure potential risks/trade-offs are identified and contingency planning with a solutions’ focused mindset.
  1. Team Effectiveness
  • Ensure cross functional partnerships and resources are leveraged effectively, and with accountability, to achieve program objectives.
  • Drive collaboration and transparency across all functions on the CT and challenge team members to be broad and inclusive in their strategy planning.
  • Resolve conflicts at the Core Team, provide and receive feedback to develop and maintain a high performing team
  1. Governance and Approvals
    • Ensure that team recommendations are brought to appropriate governance for decision
    • Ensure alignment of program strategy/plan/execution with management expectations & priorities
  2. Communication
    • Single point of contact on program for executive and functional management
    • Ensures communication of rationale and context for decisions made to team
    • Leads team in developing a comprehensive internal and external communication plan with team input for important program milestones, key data, etc.
    • Reviews and agrees to publication plan, reviews publication concepts, presentations and manuscripts
    • Primary source for information as needed for external communications (press releases, investor related, etc.)
    • Reviews health authority related documents and ensures consistency with strategic objectives for the program

Education and Requirements:

  • The successful candidate will ideally have an advanced degree in a scientific discipline (e.g. Pharm D, Ph.D. or M.D.)
  • BS. is Life Sciences is a plus.
  • Absent a medical or religious reason that prohibits vaccinations, all our incoming employees must be vaccinated.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.

About our location

San Rafael


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Meet Our Team

From internationally renowned scientists to patient advocates, BioMarin Hemophilia has brought together the right people.

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