Exec Dir / Sr. Dir, Core Team Leader: PKU – Franchise & 307Location San Rafael, California Apply
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.
About the Team:
The Core Team Leader Group is part of BioMarin’s Corporate Product Portfolio Development function which reports to the Chief Scientific Strategy Officer. Product Portfolio Development is responsible for BioMarin’s corporate and product governance, business operating model (core teams and partner teams), portfolio strategy and business financial planning, strategic business insights and Competitive Intelligence.
About the Program:
BMN 307 is BioMarin’s 2nd gene therapy asset being developed for the treatment of PKU. BioMarin is a world leader in PKU with two approved medicines (Kuvan and Palynziq) and is excited to strengthen its leadership position in PKU by developing an innovative treatment option for patients. Building on its gene therapy experience in Hemophilia A, BioMarin recently initiated the first in human study for BMN 307. BMN 307 has the potential to replace the missing PAH enzyme and reduce elevated Phenylalanine levels in patients which consequently has meaningful clinical impact on their lives.
Core Team Leader (CTL) Position:
CTL is the product champion and leads a team of functional leaders that together develop product strategy which is reviewed and approved by BioMarin governance. CTL is the primary liaison with executive management and has overall accountability to executive management for the integrated product strategy. In collaboration with core team (CT) members, the CTL ensures progress and execution against plans and as the leader of the CT is the primary contact for internal stakeholders. As a senior leader in the core team leader group, is a role model, mentors peers and contributes to key core team processes and initiatives.
10+ years of experience in the biotechnology/ pharmaceutical industry. Clinical development experience is highly preferred. Rare disease experience is a plus.
2+ years of experience leading a core/cross functional strategy team for an investigational therapy.
The successful candidate will also demonstrate strong matrix leadership ability and professional credibility to influence a highly intelligent and sophisticated audience of colleagues, partners, and external constituents.
This individual must be a self-starter and possess excellent leadership, influencing and communication skills, as they will be applied at all levels, including at the core team, interactions with the executive team, and presentations to internal and external audiences.
General CTL Responsibilities:
- Program Strategy
Lead the CT in the generation of a Target Product Profile to maximize the molecule’s potential for patients and for the business
Ensure integrated stage-based product plans that are aligned with program strategy and ensures assumptions and drivers are aligned with plans to inform financial planning
Establish strong partnerships with all functional stakeholders, specifically Medical Affairs, Regulatory and Commercial to ensure approval and launch success.
Ensure potential risks/trade-offs are identified and contingency planning with a solutions’ focused mindset.
- Team Effectiveness
Ensure cross functional partnerships and resources are leveraged effectively, and with accountability, to achieve program objectives.
Drive collaboration and transparency across all functions on the CT and challenge team members to be broad and inclusive in their strategy planning.
Resolve conflicts at the Core Team, provide and receive feedback to develop and maintain a high performing team
III. Governance and Approvals
Ensure that team recommendations are brought to appropriate governance for decision
Ensure alignment of program strategy/plan/execution with management expectations & priorities
Single point of contact on program for executive and functional management
Ensures communication of rationale and context for decisions made to team
Leads team in developing a comprehensive internal and external communication plan with team input for important program milestones, key data, etc.
Reviews and agrees to publication plan, reviews publication concepts, presentations and manuscripts
Primary source for information as needed for external communications (press releases, investor related, etc.)
Reviews health authority related documents and ensures consistency with strategic objectives for the program
The successful candidate will ideally have an advanced degree in a scientific discipline (e.g. Pharm D, Ph.D. or M.D.)
B.S. is Life Sciences is a plus.