Research Associate II - In Vivo for Hematology (Non-oncology)
Location Petaluma, California Workstyle Onsite Only Apply
Who We Are
For more than two decades, going our own way has led to countless breakthroughs, bettering the lives of those suffering from rare genetic disease. In 1997 we were founded to make a big difference in small patient populations. Now we seek to make an even greater impact by applying the same science-driven, patient-forward approach that propelled our last 25 years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Through our unparalleled expertise in genetics and molecular biology, we will continue to develop targeted therapies that address the root cause of the conditions we seek to treat. Applying our knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The end goal has always been better lives and now we can reach more.
And the more people we reach, the more our impact can grow. We transform lives through genetic discovery.
Our Culture
Our desire to make a positive impact on our patients extends to our employees and BioMarin is committed to fostering an inclusive environment where every person feels seen, valued, and heard – so employees can thrive in all areas of their lives, in and outside of work. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with the ability to develop their long-term careers. Ultimately, we want to be an organization where people enjoy coming to work and take pride in our efforts to help patients.
BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients’ lives.
We are seeking a motivated Research Associate II to join the non-oncology Hematology Therapeutic Area at BioMarin. The successful candidate will have a hands-on role in the development, optimization, and implementation of genetic rodent models of hematological diseases. The ideal candidate will have extensive in vivo experience researching genetic non-malignant hematology disorders, particularly in the context of evaluating novel therapeutic approaches (including but not limited to biologics, small molecules, and gene therapies) and mode of action. In vivo or ex vivo responsibilities include administration of test articles, liver perfusion and digestion, blood collection as well as small animal microscopic surgeries to conducting bleeding challenge models in rodents. These methodologies/protocols require optimization, so an individual who is proficient in performing In vivo procedures and ex vivo assays related to hemostasis is highly desired.
Responsibilities:
PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.
In the U.S., the salary range for this position is $ 76,000 to $ 114,000 per year, which factors in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors. A discretionary bonus and/or long-term incentive units may be provided as part of the compensation package, in addition to the full range of medical, financial, and/or other benefits, dependent on the level and position offered.
Apply For more than two decades, going our own way has led to countless breakthroughs, bettering the lives of those suffering from rare genetic disease. In 1997 we were founded to make a big difference in small patient populations. Now we seek to make an even greater impact by applying the same science-driven, patient-forward approach that propelled our last 25 years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Through our unparalleled expertise in genetics and molecular biology, we will continue to develop targeted therapies that address the root cause of the conditions we seek to treat. Applying our knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The end goal has always been better lives and now we can reach more.
And the more people we reach, the more our impact can grow. We transform lives through genetic discovery.
Our Culture
Our desire to make a positive impact on our patients extends to our employees and BioMarin is committed to fostering an inclusive environment where every person feels seen, valued, and heard – so employees can thrive in all areas of their lives, in and outside of work. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with the ability to develop their long-term careers. Ultimately, we want to be an organization where people enjoy coming to work and take pride in our efforts to help patients.
BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients’ lives.
We are seeking a motivated Research Associate II to join the non-oncology Hematology Therapeutic Area at BioMarin. The successful candidate will have a hands-on role in the development, optimization, and implementation of genetic rodent models of hematological diseases. The ideal candidate will have extensive in vivo experience researching genetic non-malignant hematology disorders, particularly in the context of evaluating novel therapeutic approaches (including but not limited to biologics, small molecules, and gene therapies) and mode of action. In vivo or ex vivo responsibilities include administration of test articles, liver perfusion and digestion, blood collection as well as small animal microscopic surgeries to conducting bleeding challenge models in rodents. These methodologies/protocols require optimization, so an individual who is proficient in performing In vivo procedures and ex vivo assays related to hemostasis is highly desired.
Responsibilities:
- Organize and maintain mouse colonies
- Assist in the design and execution of in vivo model systems/proof of concept studies to understand mechanisms underlying AAV gene therapy efficacy, variability, and durability
- Assist in the development of new techniques and/or optimization of current techniques to assess efficacy of therapies targeting the hemostasis system
- Perform in vivo lab experiments including but not limited to dosing (ip, iv, sc, im, etc.) studies, husbandry, vessel injury, bleeding risk assessment, and whole blood/tissue collections.
- Recognize and adhere to IACUC standards of in vivo research
- Perform data recording and statistical analysis; Document all experimental procedures and data in electronic notebook
- Engage with project teams in a collaborative manner
- Share responsibility for lab maintenance duties
- Other duties as assigned
Requirements:
- Proficiency with standard in vivo operations: Animal handling, anesthesia, drug dosing (i.v. injections), tissue and blood collections.
- Basic understanding and knowledge of hematology with an emphasis on coagulation, thrombosis and hemostasis are highly desirable
- Basic knowledge of and hands-on experience with rodent in vivo and ex vivo models of hemostasis and bleeding is highly preferred
- In vivo surgical experience is preferred
- Ability to work independently as well as collaboratively in a dynamic environment
- Strong organizational and time-management skills and a desire to learn new techniques
- Computer skills such as experience with Microsoft Word, Excel, PowerPoint, GraphPad Prism.
- Excellent oral and written English communication skills
Education/Experience
- Bachelor (BS / BA) degree in a biological or biochemical field with 4+ years experience, Masters (MS) degree in a biological or biochemical field, with 2 years work experience in in vivo experimentation.
Persons without in vivo experience need not apply.
PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.
In the U.S., the salary range for this position is $ 76,000 to $ 114,000 per year, which factors in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors. A discretionary bonus and/or long-term incentive units may be provided as part of the compensation package, in addition to the full range of medical, financial, and/or other benefits, dependent on the level and position offered.