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Scientist 1

Location Novato, California


BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.  

BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. The Analytical Chemistry department, a part of Process Sciences within Tech Ops, supports all assay needs in Tech Ops. Our scientists and associates are experts in analytics of small molecules, peptides, complex glycosylated enzymes, PEGylated proteins and gene therapy agents. We develop assays to follow the quality attributes of our products, support IND and BLA applications, we assess the capability of our processes by analyzing in-process samples all the way from bioreactors through purification steps to the drug substance and build release assays for transfer to Quality. We are also instrumental in time-critical analysis support to Manufacturing as needed. Come join our team and make a meaningful impact on patients’ lives.  


The Analytical Chemistry department at BioMarin Pharmaceutical Inc. is seeking a Molecular and Cellular Virologist/Biologist at the Scientist 1 level with adenovirus associated virus (AAV) vector analytical/assay development expertise to join a team focused on supporting gene therapy efforts to address genetic disorders. The successful candidate will be a self-motivated critical thinker, with a proven ability to work in  
a multi-disciplinary and collaborative environment. The candidate will develop and utilize a wide variety of  analytical methods and assays for the characterization of gene therapy agents in our pipeline.An ideal candidate would be well-versed in analytics for viruses and viral vectors as appropriate for development of  gene therapy products and processes. Experience in a drug development environment is a big plus.  


Execution of relevant experiments to support development of qualitative and quantitative assays
for gene therapy process development as well as product characterization.  

Primarily support development of biochemical and molecular methods to analyze viral DNA, RNA, protein, and infectivity, vector genome titers, capsid composition, vector potency, transduction, etc.  

Conduct experiments to support vector characterization, safety studies, comparability studies, and stability studies in a timely fashion.  

Routinely share experimental data with project teams and write protocols and reports.  

Train colleagues and associates when needed.  

Serve as a resource in virology, vector biology, and AAV to colleagues in the Development organization within the company.  


Required Skills:  

Expert in molecular and cellular virology and vector biology  

Experience with virus and vector characterization  

Knowledge of AAV structure, biology, and vector transduction  

Collaborative skills to work in a cross-functional environment  

Skillful in developing analytical techniques to enhance understanding of viruses and vectors  

Strong communication, collaboration and writing skills  

Proven data analysis, interpretation and scientific communication skills  

Proven flexibility and execution skills to deliver in a fast-paced environment

Desired Skills:  
Cell isolation and identification  

Cell differentiation and functional characterization  

Direct training and work experience with viruses and viral vectors.  


Flow cytometry  

Biochemistry methods  

Molecular biology methods  


Ph.D. in virology, biological sciences, or biochemistry and 2 years of post-doctoral or industry experience is preferred.  


Operation of standard PCR, ddPCR, qPCR, flow cytometry, DNA sequencing, microscopy desired.  


Will report to the Principal Scientist managing AAV/Immunochemistry group within Analytical Chemistry. 


No immediate supervisory role.  

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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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