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Research Associate 2/Sr. Research Associate, Molecular Biology, Cell Cultured Process Development

Location Novato, California
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Cell Culture Process Development group is responsible for designing and scaling up the cell culture processes for production of:
  • Biomolecules including proteins for enzyme replacement therapies.
  • Viral vectors for gene therapies.

We are seeking an experienced Research Associate for research and development activities. The successful candidate will be part of an established team of scientists and RAs working to develop and optimize recombinant adeno-associated virus (AAV) vector production processes. He/she will assists the team members with tasks in the area of molecular biology and cell culture.

RESPONSIBILITIES

The responsibilities include but are not limited to:

  • Nucleic acid/plasmid purification.
  • Cell propagation and plasmid transfection. Clone screening and selection.
  • DNA analysis by agarose gel electrophoresis. PCR.
  • DNA quantification by qPCR and ddPCR.
  • Protein analysis by ELISA, Western blot.
  • Thorough documentation of procedures and results.
  • Flexibility and willingness to accept new responsibilities.
  • Perform reliably in a fast-paced environment.
  • Handle multiple tasks efficiently.
  • Closely interact with other team members. Develop internal and external collaborations.
  • Present results and conclusions in group and department meetings.

EXPERIENCE

Required:

  • Molecular biology and cell culture work experience, preferentially in an industrial laboratory.
  • Good organization, data analysis, and interpretation skills.
  • Critical thinking, good interpersonal, verbal, and written communication skills.
  • Proficiency in Microsoft Word, Excel, and PowerPoint.

Desired:

  • Hands-on experience with recombinant AAV vectors and baculovirus expression system.
  • Insect or mammalian cell culture, transient and stable transfection.
  • Analytical assays: qPCR, ddPCR, ELISA, electrophoresis, Western blot, and cell-based assays.

EDUCATION

Minimum: Bachelor’s degree with 5+ years or Master’s degree with 2+ years of laboratory experience in molecular or cell biology.

BioMarin is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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