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Research Associate 1/2

Location Novato, California Workstyle Onsite Only

BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients

SUMMARY:

The Cell Culture Process Development department at BioMarin Pharmaceutical Inc. is seeking to fill a full-time position for aResearch Associatein upstream research and development. The successful candidate will work both independently and as part of a team focusing on optimizing production of recombinant viral vectors for the company’s gene therapy programs.

RESPONSIBILITIES:

  • Buffer and media preparation
  • Cell line maintenance, expansion, transfection
  • Production, harvest, and purification of viral material
  • Perform associated analytical assays
  • Diligently document the results
  • Maintenance of laboratory equipment
  • Flexibility in a fast-paced, changing environment; be willing to accept responsibilities outside of the initial job description
  • Handle multiple tasks efficiently
  • Closely interact with other team members; develop internal and external collaborations
  • Present results and conclusions in group and department meetings; write reports

EXPERIENCE

Required:

  • Good working knowledge of chemistry and biochemistry principles
  • Aseptic culturing technique
  • Hands-on experience in suspension or adherent cells culturing
  • Critical thinking, data analysis and interpretation skills
  • Good interpersonal, verbal, and written communication skills
  • Proficiency in Microsoft Word, Excel, and PowerPoint

Desired:

  • Experience with mammalian cell cultures, metabolite measurement, cell count and viability measurements
  • Working knowledge of rAAV production process, transfection
  • Experience with any of the following analytical techniques: flow cytometry, ddPCR/qPCR, Western Blotting, ELISA, Bio-Layer Interferometry (Octet), total protein assay, cell based assays.
  • Knowledge of Ambrbioreactor operation is a plus
  • Knowledge of JMPsoftwareand Design of Experiments principles is a plus

EDUCATION

Minimum: Bachelor’s degree in biological sciences or in a related field with 2+years of experience in a cell culture laboratory.

Preferred: Bachelor’s degree with 4+ years or Master’s degree with 2+ years of experience in industrial research and development.

PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.



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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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