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Research Assistant

Location Novato, California


The Research Assistant is involved with the design of protein purification processes suitable for manufacturing therapeutic proteins, and with the transfer of those processes to manufacturing facilities. The Associate works primarily in the laboratory to design, carry out, and analyze experiments that lead to effective purification processes.


The research associate will receive general supervision. The applicant must exercise some technical discretion in the design and execution of varied experiments and projects. He or she provides quantitative analysis of data and interpretation of results, writes protocols, and contributes to technical reports. At times, he or she may evaluate complex methods, technologies, or laboratory equipment. He or she may adapt existing processes and develop new processes.

The research associate may provide assistance to manufacturing start-up, troubleshooting, and validation. He/she will be expected to contribute to scientific publications and regulatory submissions and may attend external seminars.

More specifically, this position requires the following roles. The primary focus is laboratory experimental work:

  • Execute small-scale experiments to design, optimize, and characterize purification processes.
  • Perform experiments to determine operational ranges and robustness for various steps in purification processes.
  • Perform and troubleshoot analytical assays required to support experiments (e.g., UV absorbance, SDS-PAGE, HPLC, enzyme activity and ELISA).
  • Assist with process scale-up and transfer into the clinical manufacturing plant.
  • Order materials for the laboratory and maintain equipment and facility through targeted preventive maintenance.
  • Use pilot-scale equipment to process cell-culture harvests for further experiments and to prepare purified proteins for research.

This position involves close collaboration with cell culture, analytical, manufacturing sciences, and clinical manufacturing groups.


Required Skills:

  • Experience should include 0 – 2 years of applicable work experience (with a bachelor’s degree) in protein purification and characterization.
  • Technical proficiency in chromatography, ultrafiltration, SDS-PAGE, Western blotting, HPLC, ELISAs and spectrophotometry are particularly desirable, allowing for the effective execution and analysis of experiments.
  • The research associate should be able to use computers effectively for data analysis and presentations.
  • Candidates should have good organizational and communication skills, and an interest in developing technical skills to move into increasing levels of responsibility in experimental design.
  • The candidate should have some experience in documenting results in Technical Reports
  • The candidate must be capable of working and communicating effectively in cross-function teams.


A four-year degree in biological science, chemistry, or chemical engineering, plus 0 to 2 years of applicable work experience.


Laboratory equipment, such as analytical instruments and chromatography workstations; pilot processing equipment, such as pumps, filtration devices, and chromatography skids.


The research assistant will be expected to effectively interact with other research assistants and associates, scientists and senior scientists within Process Sciences. Other contacts may include people from the following departments: Process Analytics, Analytical Chemistry, Quality Control, Formulation, Manufacturing, Validation and Project Managers.



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