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Intern, Biophysical Characterization

Location Novato, California

BioMarin is leading the biotechnology industry in delivering therapies for chronic and degenerative genetic conditions that lead to short life span and reduced quality of life for affected patients. We focus on diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. BioMarin will continue to focus on advancing therapies that are the first or best of their kind and make a big difference in improving patients' lives.

The Biophysical Characterization group is involved in biochemical and biophysical characterization of gene therapy vectors as well as different protein-based drug products including enzymes for enzyme replacement therapies.  Our group is focused on understanding all the aspects of viral capsid and protein structure and functionality to provide information to develop methods to produce and purify stable gene therapies and biologics.

SUMMARY

The 2019 internship will focus on characterization of viral vector stability using equipment and assay procedures commonly used by biochemists and biophysicists including fluorescence spectroscopy, circular dichroism, light scattering, size-exclusion chromatography, calorimetry and analytical ultracentrifugation. 

RESPONSIBILITIES

  • Carry out well-defined experiments
  • Make detailed observations and provide quantitative data analysis
  • Follow written procedures, noting when they need updating; may assist in rewriting procedures.
  • Participate with others to evaluate new methods and technologies
  • The intern will use equipment commonly found in a lab conducting research in biochemistry or protein structural biology. Training will be provided.

WORK ENVIRONMENT/PHYSICAL DEMANDS

The employee may frequently be required to sit and talk or listen.  The employee is occasionally required to stand; walk; use hands to finger, handle, or feel; reach with hands and arms; climb or balance; stoop, kneel, crouch, or crawl and taste or smell.  The employee must occasionally lift and/or move up to 25 pounds.  Specific vision abilities by this job include close vision, depth perception and ability to adjust focus.


CONTACTS

The intern may interact with personnel from a variety of cross-functional groups, including Process Development and Pre-Formulation, Formulation, Process Analytics, and Analytical Chemistry. 


Qualifications/Eligibility: 

  • Must be pursuing either a Bachelor’s or Master’s degree in a field related to the Biopharmaceutical Industry (Biology, Biochemistry, Chemistry, Chemical Engineering or related field). 
  • At a minimum, the candidate should be enrolled in their second (sophomore) year of undergraduate study at the time of application. Preference will be given to candidates with lab experience.
  • Student must be returning to school in the Fall Term OR has graduated within the 1 year of the start of the intern program.   
  • Must be available to work 40 hours a week 
  • Housing and Transportation is responsibility of the Intern 


Benefits of a BioMarin Internship: 

  • Apply skills and knowledge learned in the classroom to on-the-job experiences 
  • Comprehensive, value-added project(s) 
  • Work in teams and with colleagues in a professional environment 
  • Develop technical skills specific to your major 
  • Provides opportunities for professional development by building relationships and learning about other parts of the business 
  • Weekly lunch seminar series with Executive Staff  
  • End of summer poster presentation to the BioMarin Community 

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law. 

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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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