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Oncology Genomics Lead

Location London, United Kingdom Workstyle Open to Hybrid
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.

BioMarin is looking for a candidate with a background in cancer genomics – having worked with both germline and somatic data to identify risk factors for and drivers of tumorigenesis. The role’s primary goal will be to drive the generation of omics data from oncology-related samples within BioMarin’s clinical and post-approval studies. This will require the candidate to have a strong scientific skillset, but also the ability to engage with the relevant clinical teams to ensure the right scientific questions are being asked and the right samples collected & data generated to answer them.

This role will offer an exciting opportunity for candidates who wish to take their expertise in analysing genomic data into the later stages of the drug development pipeline. We believe there are currently huge opportunities for genetics to improve the design of trials, allow for innovative analyses of clinical data, and ultimately help improve patient outcomes. As this is a relatively new effort at BioMarin, it also provides an exciting opportunity for the candidate to join a growing team and influence our clinical genomics strategy going forward.

The role will be based out of either our London or San Rafael office. However, as it will include close collaboration with our colleagues at scientific and clinical sites across the globe, we are happy to consider applicants who would want to work remotely in Europe (with some restrictions). 

Responsibilities:

  • Develop strategies and protocols for the collection and management of oncology genomic samples & data within both clinical and real-world studies
  • Analysis of genomics data (e.g. whole genome sequencing) to identify somatic and germline variants that may influence cancer risk or other patient variability
  • Provide expertise in cancer genomics in discussions with clinical and research partners, and lead the interpretation of their implications
  • Communicate findings to internal partners and in written reports – including those that will be provided to regulators during approval process and to answer post-marketing requests
  • Build collaborations within BioMarin and externally to establish infrastructure needed for oncology genomics efforts – e.g. collaborations with academic groups, access to relevant biobanks and database, a data management framework, etc.

Required Experience:

  • PhD in cancer genomics, statistical genetics or a related field, with experience performing analysis of tumour omics data
  • Experience leading research projects, particularly those using clinical trial data and/or collaborations spanning multiple sites/countries
  • The ability to engage with internal and external partners to understand and identify the key scientific questions within a clinical trial and/or therapeutic programme
  • Strong analytical skills, as well as experience coding (e.g. R, Python, Shell, Hail), using HPC or cloud based systems (e.g. DNAnexus), and developing and documenting analytic pipelines
  • A clear track-record of excellent scientific communication through publications and conference presentations

Additional Ideal Experience:

  • Experience using RNA-Seq data
  • Experience in integration site analysis
  • Experience with animal models of cancer
  • 2+ years of experience post PhD, with previous experience working in industry or with clinical trial data
  • Experience working with regulators and/or on therapeutics in the late stages of clinical development

PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.

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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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