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Senior Associate Scientist, MSAT Purification

Location Cork, Ireland
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. Come join our team and make a meaningful impact on patients’ lives.

SUMMARY DESCRIPTION

The Snr. Associate Scientist, Purification will provide scientific expertise on a variety of small-scale protein purification techniques to support process characterization, trouble-shooting of manufacturing issues, and continuous process improvement.

The candidate should have experience in bio-processing of proteins (Enzymes, Antibodies), and more specifically have hands on expertise of small-scale laboratory purification techniques (e.g. AKTA systems) such as affinity, size exclusion and ion-exchange chromatography.  The candidate will be involved in various cross functional projects that will involve high standards of collaboration with scientific peers across MSAT, Process Development, Manufacturing, Quality and Engineering.


RESPONSIBILITIES

  • Accountable for delivering assigned scientific projects & studies in line with overall MSAT business plan, with limited supervision.
  • Accountable for the integrity of the data and scientific conclusions from assigned scientific projects.
  • Accountable for assigned laboratory equipment use and maintenance. (i.e. equipment owner)
  • Accountable for the health and safety of self and colleagues working together.
  • Accountable for developing and maintaining expertise in protein purification techniques and methodologies.
  • Accountable for developing & maintaining a high standard of Good Laboratory Practices (GLP).
  • Accountable for developing and maintaining your Individual Development Plan (IDP) through training, mentoring and coaching.
  • Responsible for developing cross functional project plans with other MSAT SME’s and stakeholders.
  • Responsible for adhering to MSAT procedures and practices specifically in relation to laboratory operations.
  • Responsible for participating in the internal network of SME’s across the scientific and technical functions namely MSAT, Process Sciences and R&D etc.
  • Responsible for the communication and dissemination of scientific output to scientific & technical functions and MSAT stakeholders. (i.e. presentations to internal functions)
  • Responsible for designing discrete studies/experiments with appropriate supervision.
  • Responsible for maintaining a culture of empowerment, accountability and continuous improvement within MSAT.
  • Responsible for contributing to a culture of scientific excellence across the scientific functions namely MSAT, Process Sciences & R&D.
  • Responsible for contributing to strong cross functional relationships through promotion of science and the work of MSAT across stakeholder groups, specifically Technical Operations functions.
  • Responsible for maintaining a culture of Operational Excellence, namely Standard work and 5S.

EDUCATION

Sr. Associate Scientist: Master's degree in a relevant scientific discipline with 3+ years’ experience of laboratory scale purification techniques. Bachelor's degree with 5+ years’ experience of laboratory scale purification techniques. 

EXPERIENCE 

Sr. Associate Scientist: Master's degree in a relevant scientific discipline with 3+ years’ experience of laboratory scale purification techniques. Bachelor's degree with 5+ years’ experience of laboratory scale purification techniques. 


WORK ENVIRONMENT / PHYSICAL DEMANDS

Laboratory work and manufacturing support activities will require the use or proximity of chemicals, laboratory and manufacturing equipment and instruments, and mechanical moving parts.  Noise and vibration may be present.

Periodic week-end laboratory work and/or on call support will be required on a team rotation basis.


EQUIPMENT 

Equipment related to cell culture and/or purification, as well as analytical instruments typical in biopharmaceutical labs and manufacturing

CONTACTS

  • MSAT
  • Manufacturing
  • Quality and Validation
  • Quality Control
  • Process Sciences
  • Facilities Services

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

About our location

Cork

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We treat rare diseases, and that gives us rare opportunities. Chris Brodeur, Director, Corporate Compliance
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